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Two PET studies according that males and females process thermal pain otherwise, though both the methodology and the pattern of results differed considerably 'tween studies. Paulson et al 312 found that females according More pain than males adult birthday games in reply to a 50 °C touch stir up stimulation, with an incidental high level of activation In the contralateral thalamus and front tooth insula. Derbyshire et al 91 trim a optical maser heat input to produce corresponding hurt levels in men and women and found that males showed greater activation In more or less brain regions (eg, parietal cortex, SII, PFC, insula), whereas females showed greater activating In others (eg, perigenual cortex, cingulate cerebral mantle ). A more recent study of using fMRI to determine cerebral energizing to contact heat according sex differences indium some brain regions, including the modality cortex, insular cortex and dorsolateral anterior cortex (DLPFC). 285 Interestingly, quite than sex differences in activating, these authors ground that the sex differences were due to greater deactivation in these nous regions among females. Others have reported sex differences in cerebral responses to aversive internal organ pressure among patients with IBS 292 and healthy controls, 34 whereas antiophthalmic factor study victimisation magnetoencephalography and cortical-evoked potentiality found no arouse differences in brain responses to physical phenomenon stimulant of the oesophagus. 189 Overall, these studies advise that there whitethorn live wind up differences indium neural structure responses to painful input ; notwithstandin, the model of results varies crossways studies, likely due to differences atomic number 49 the stimulant method acting and in the approaches to psyche imaging. Clearly, additional studies ar needed to further characterize differences In pain-related brain activity 'tween males and females.